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The development process of China,s electric locomotive manufacturing system is reviewed.The situation and development trend of developed countries are introduced.By analyzing the challenges confronting China,s electric locomotive manufacturing industry,the author puts forward the counter measure to catch up with the world level——to establish information integrated manufacturing system (electric locomotive CMIS). The conception of establishing a 21 century oriented integrated manufacturing system for Zhuzhou Electric Locomotive Works is depicted from aspects of technology direction,further innovations,integration of CAD/CAE/CAPP/CAM and establishing of MIS CMIS.